NES
Nestle Research Center - Lausanne
Research and Training Expertise
Nestlé
Key persons involved
After a PhD at the Université Libre de Bruxelles (BE, 1980) and a post-doc at the ETH of Zurich (CH), Annick Mercenier joined a small biotechnology company, Transgène S.A. (FR) for 14 years. In 1996, she joined the Institut Pasteur de Lille (FR) to set up the Department of Microbiology of Ecosystems while she was heading the Bacteriology laboratory (health applications of LAB). She has coordinated 3 successive EU programmes. In 2002, she has taken a position of group leader in the Nutrition and Health Department of the Nestlé Research Center in Lausanne (CH). She has expertise in the genetics and metabolic pathways of gram-positive bacteria of industrial interest, mucosal immunology, probiotics and interaction between the microbiota and the host immune system.
Guénolée Prioult, PhD. Since her PhD in food immunology and a postdoctoral fellowship in cellular mechanisms of allergic diseases (MGH, Harvard Medical School, Boston), she has developed expertise in the modulation of immune disorders (allergies, gut inflammation...) by probiotic supplementation as well as the cellular mechanisms involved in oral tolerance induction.
Material Ressources
Cellular and molecular immunology (FACS, ELISA, cytokine arrays, RT-PCR, cell culture, etc). animal facility (conventional and GF). Animal models for oral tolerance/allergy. Probiotic collection. Genetics and (post)genomics of probiotics. Platforms for transcriptomics, proteomics and metabolomics.
3 Key publications
- Nutten S, Schumann A, Donnicola D, Mercenier A, Rami S, Garcia-Rodenas CL. (2007) Antibiotic administration early in life impairs specific humoral responses to an oral antigen and increases intestinal mast cell numbers and mediator concentrations. Clin Vaccine Immunol. 14:190-7.[Pubmed]
- Klijn A, Moine D, Delley M, Mercenier A, Arigoni F, Pridmore RD. (2006) Construction of a reporter vector for the analysis of Bifidobacterium longum promoters. Appl Environ Microbiol. 72:7401-5.[Pubmed]
- Corthésy B, Gaskins HR, Mercenier A. (2007) Cross-talk between probiotic bacteria and the host immune system. J Nutr. 137:781S-90S. [Pubmed]




