UO

Laboratory for Immunohistochemistry and Immunopathology (LIIPAT) - University of Oslo - Division of Pathology, Rikshospitalet - Oslo

The Laboratory for Immunohistochemistry and Immunopathology (LIIPAT) is located at the Institute of Pathology, Faculty of Medicine, University of Oslo, and the Division of Pathology, Rikshospitalet University Hospital. Mucosal Immunology is the scientific focus of the group, which has collaboration with various clinical departments at Rikshospitalet and other University Hospitals as well as with several research institutions in Norway and abroad. LIIPAT is one the 5 groups in the Centre for Immune Regulation (CIR), which has been selected as a Centre of Excellence by the Research Council of Norway.

Per Brandtzaeg, DDS, MS, PhD is the founder of LIIPAT. He has over the last two decades been the leading Norwegian scientist in all fields on the Institute of Scientific Information’s high-impact list, publishing more than 600 peer-reviewed original papers. He has received 14 awards all over the world. As a teacher, he has given ~300 contributions to postgraduate courses, ~680 invited lectures for various universities and societies, and supervised 40 doctoral dissertations.

Information about the Ph.D. program at University of Oslo medical faculty can be found here.

Key persons involved

Finn-Eirik Johansen, PhD is Prof. at UO and the current Head of LIIPAT. He completed his PhD at Columbia University 1994 (New York, NY, USA).  He was awarded several prizes including the John S Newberry Prize for best Ph.D. in vertebrate biology at Columbia University, and has published 55 articles in peer-reviewed journals.

Research and Training Expertise

LIIPAT is internationally recognized in mucosal immunology and inflammation and with its collaborators in CIR possesses all the necessary skills for biomedical research, from molecular and cell biology to live imaging. We have generated a knockout mouse that lacks secretory immunity (pIgR-/-); this strain is an interesting “tool” in studies of mucosal immunity–commensal interactions.

Material Ressources

Animal facility including transgenic centre and live imaging (Xenogen IVIS Spectrum), molecular biology including 4 colour real-time PCR, fluorescence microscopy including con-focal and live con-focal, electron microscopy, cell and tissue culture, FACS analysis and sorting.

There is available student accommodation (University housing) within walking distance from the hospital and other locations in the city of Oslo. Information can be found here.

Key publications

  • Sollid LM, Johansen FE (2008) Animal Models of Inflamatory Bowel Disease ar the Dawn of the New Genetics Era. PLoS Med 5(9): e198 doi:10.1371/journal.pmed.0050198
  • Wijburg OL, Uren TK, Simpfendorfer K, Johansen FE, Brandtzaeg P, Strugnell RA.(2006) Innate secretory antibodies protect against natural Salmonella typhimurium infection. J Exp Med., 203:21-6.[Pubmed]
  • Yamanaka T, Helgeland L, Farstad IN, Fukushima H, Midtvedt T, Brandtzaeg P. (2003) Microbial colonization drives lymphocyte accumulation and differentiation in the follicle-associated epithelium of Peyer's patches. J Immunol., 170:816-22.[Pubmed]
  • Johansen FE, Pekna M, Norderhaug IN, Haneberg B, Hietala MA, Krajci P, Betsholtz C, Brandtzaeg P. (1999) Absence of epithelial IgA transport, with increased mucosal leakiness, in pIgR/SC-deficient mice. J Exp Med 190:915-21